Review: Endovascular treatment and carotid endarterectomy do not differ for carotid stenosisPDF
ACP J Club. 2005 Sep-Oct;143:35. doi:10.7326/ACPJC-2005-143-2-035
Clinical Impact Ratings
Coward LJ, Featherstone RL, Brown MM. Safety and efficacy of endovascular treatment of carotid artery stenosis compared with carotid endarterectomy: a Cochrane systematic review of the randomized evidence. Stroke. 2005;36:905-11. [PubMed ID: 15746454]
In patients with carotid stenosis, what are the risks and benefits of endovascular treatment compared with carotid endarterectomy?
Data sources: Cochrane Stroke Group Specialized Register (September 2003), Cochrane Central Register of Controlled Trials (Issue 3, 2003), MEDLINE (1966 to October 2004), EMBASE/Excerpta Medica (1980 to October 2004), Science Citation Index (1981 to October 2004), conference proceedings, researchers in the field, and balloon catheter and stent manufacturers.
Study selection and assessment: Randomized controlled trials that compared carotid endovascular treatment with carotid endarterectomy in patients with symptomatic or asymptomatic carotid artery stenosis. Quality of individual studies was assessed for method of randomization, allocation concealment, intention-to-treat analysis, blinded outcome assessment, and follow-up.
Outcomes: Death or any stroke at 30 days; death or disabling stroke at 30 days, death or any stroke at 1 year; cranial neuropathy at 30 days; and death, any stroke, or myocardial infarction at 30 days.
5 trials (n = 1269) met the inclusion criteria. 75% of patients were symptomatic. Blinding of intervention or outcome was not present in any trial, but allocation concealment was adequate in all trials. Endovascular treatment reduced cranial neuropathy; groups did not differ for any other outcome (Table).
In patients with carotid stenosis, no difference exists in risks or benefits between endovascular treatment and carotid endarterectomy.
Source of funding: No external funding.
For correspondence: Dr. M.M. Brown, National Hospital for Neurology and Neurosurgery, London, England, UK. E-mail firstname.lastname@example.org.
Table. Endovascular treatment vs carotid endarterectomy for carotid artery stenosis*
|Outcomes||Number of trials (n)||Weighted event rates||RRI (95% CI)||NNH|
|30-d death or any stroke||5 (1269)||8.3%||6.3%||29% (−13 to 91)||Not significant|
|30-d death or disabling stroke||3 (716)||5.5%||4.5%||19% (−36 to 123)||Not significant|
|1-y death or any stroke||3 (1057)||13.4%||13.3%||1% (−26 to 37)||Not significant|
|30-d death, stroke, or myocardial infarction||5 (1269)||8.1%||7.8%||4% (−28 to 50)||Not significant|
|RRR (CI)||NNT (CI)|
|30-d cranial neuropathy||4 (1050)||0.5%||6.5%||96% (78 to 99)||17 (12 to 25)|
*Abbreviations defined in Glossary; weighted event rates, RRI, RRR, NNH, NNT, and CI calculated from data in article using a fixed-effects model.
Endovascular therapy (carotid angioplasty and/or stenting) for carotid stenosis has great appeal. It is less invasive than carotid endarterectomy, has lower rates of cranial nerve injury, and may even be less expensive. The key question is whether endovascular therapy is as good as or better than carotid endarterectomy. Coward and colleagues found no difference in outcomes at 30 days (stroke or treatment-related death and stroke, any death, or myocardial infarction) or at 1 year (stroke or death).
It is discouraging to see the small number of patients included in randomized trials and thus the limited data. Only 3 of the included trials were multicenter studies. One of them, the WALLSTENT study, favored surgery (1). The SAPPHIRE study was terminated because recruitment slowed after nonrandomized stent registries were established; however, carotid stenting was not found to be inferior to carotid endarterectomy (2).
Substantial heterogeneity and wide confidence intervals for the endpoints exist among the trials. Important differences between surgery and endovascular therapy may have been missed. Basic questions remain about who should do the procedure and how (e.g., the use of distal protection devices to “catch” embolic material) are unanswered. Trials and registries report complication rates that exceed national guidelines (especially for patients with asymptomatic disease). No studies have yet reported long-term outcomes and rates of restenosis.
In addition, few data exist to guide decisions for the care of individual patients. Older symptomatic patients benefit from carotid endarterctomy, but do worse with endovascular therapy (3). However, endovascular therapy may be the only alternative in technically difficult cases (e.g., distal stenosis or stenosis from radiation injury).
Carotid endartectomy is the standard and should remain so until clinical trial data firmly establish endovascular therapy as a safe and effective alternative.
Lawrence M. Brass, MD
Yale University School of Medicine
New Haven, Connecticut, USA
2. Yadav JS, Wholey MH, Kuntz RE, et al. Protected carotid-artery stenting versus endarterectomy in high-risk patients. N Engl J Med. 2004;351:1493-501. [PubMed ID: 15470212]
3. Hobson RW 2nd, Howard VJ, Roubin GS, et al. Carotid artery stenting is associated with increased complications in octogenarians: 30-day stroke and death rates in the CREST lead-in phase. J Vasc Surg. 2004;40:1106-11. [PubMed ID: 15622363]