Incidence of long-term backache was similar between women who received epidural analgesia during labor and those who did notPDF
ACP J Club. 2001 Sep-Oct;135:65. doi:10.7326/ACPJC-2001-135-2-065
Howell CJ, Kidd C, Roberts W, et al. A randomised controlled trial of epidural compared with non-epidural analgesia in labour. BJOG. 2001 Jan;108:27-33. [PubMed ID: 11213000]
Does epidural analgesia during labor lead to long-term backache more than nonepidural analgesia?
Randomized (allocation concealed*), unblinded,* controlled trial with 12-month follow-up.
Maternity unit of a district general hospital in Staffordshire, England, UK.
369 women (mean age 24 y) at first pregnancy who were in spontaneous full-term labor had a normal obstetric and medical history, had no contraindication to either form of analgesia, were willing to participate, and had continued eligibility at time of labor. Follow-up was 85% at 3 months and 88% at 12 months.
Women were allocated to epidural analgesia (n = 184) or nonepidural analgesia (n = 185). Epidural analgesia consisted of 0.25% bupivacaine (10 mL) with top-ups of 5 to 10 mL of 0.25% bupivacaine by the midwife as required. Nonepidural analgesia consisted of 50 to 100 mg of intramuscular pethidine, which could be repeated according to standard practice. Entonox was available to both groups. Labor was managed according to standard protocols.
Main outcome measures
Incidence of long-term backache. Secondary outcomes were operative delivery rates and maternal satisfaction. All outcomes were measured using a maternal health questionnaire.
Analysis was by intention to treat. 61 women (33%) in the epidural group did not receive the allocated epidural, and 52 women (28%) in the nonepidural group received an epidural. No differences existed in middle or lower back pain at either 3 or 12 months after delivery (Table). In the epidural group, duration of second-stage labor was increased by 19 minutes (95% CI 6.5 to 30.9, P = 0.003) and the rate of instrumental delivery was higher (30% [epidural] vs 19% [nonepidural], P = 0.03). Cesarean-section rates were similar between groups. Maternal satisfaction with the experience of childbirth and pain relief was similarly high in both groups.
Incidence of long-term backache was similar between women receiving epidural analgesia and those receiving nonepidural analgesia during labor.
Sources of funding: WellBeing and North Staffordshire Medical Institute.
For correspondence: Mr. R.B. Johanson, Academic Department of Obstetrics and Gynaecology, North Staffordshire Hospital (NHS) Trust, Newcastle Road, Stoke on Trent, Staffordshire ST4 6QG, England, UK. FAX 44-1782-552695.
Table. Epidural vs nonepidural analgesia during labor for backache at 3 and 12 months†
|Outcomes||Follow-up||Event rates||RRI (95% CI)||NNH|
|Low backache||3 mo||35% vs 34%||0.4% (-26 to 36)||Not significant|
|12 mo||35% vs 27%||28% (-7.3 to 79)||Not significant|
|Middle backache||3 mo||22% vs 20%||8.7% (-29 to 68)||Not significant|
|12 mo||16% vs 16%||1.0% (-63 to 40)||Not significant|
†Abbreviations defined in Glossary; RRR, RRI, NNT, NNH, and CI calculated from data in article.
Epidural analgesia during labor is an effective method of relieving pain and has been used extensively since the mid-1970s, even in developing countries. Unfortunately, it has been widely incorporated into practice without enough evidence about its possible benefits and side effects. It is therefore not surprising that epidural analgesia has been blamed for a number of adverse events. This study by Howell and colleagues is the first randomized controlled trial (RCT) to specifically address the issue of postdelivery backache.
A limitation of this trial is that we may not be able to generalize the results because only 31% (875 of 2840) of all pregnant women attending the antenatal clinic were willing to participate. Of these, another 506 women withdrew in labor before randomization. Thus, only 42% (369 of 875) of women were eventually randomly allocated. A further problem was that nearly a third of the women in each group did not receive the allocated treatment, which reduces the power of the study.
Women in labor who request pain relief should be fully informed about the benefits and possible risks of their choice of analgesia (1). There are still many unanswered questions about different pain-relief methods (e.g., effect on fetus or neonate), which need to be addressed with further RCTs.
This study provides evidence to show that epidural analgesia is not a significant factor in causing postpartum backache. Women who have epidural analgesia are still satisfied with their overall experience of labor.
Cheryl Nikodem, DCur
ECRU/University of the Witwatersrand
Johannesburg, South Africa